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Journal Of Pharmacy And Pharmacological Research Vol. 3(1) pp.1 - 10 August 2013
Available online http: http://www.globalresearchjournals.org/journal/jppr
Copyright ©2013 Global Research Journals
Full Length Research.
Insulin treatment alters some biochemical parameters in potassium adapted streptozotocin-induced diabetic rats.
O. J Owolabi * and E. K .I Omogbai
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin. Benin City, Edo State, Nigeria.
*Corresponding author’s: josphineomo@yahoo.com, owolabi@uniben.edu ,Phone no: +2348034120318
| Abstract |
Insulin is the main drug for type 1 and 2 diabetes mellitus who are non responsive to oral hypoglycaemic drugs. This study is geared towards assessing the outcome of treating potassium adapted and non-adapted diabetic rats with insulin. The diabetic and non-diabetic rats (potassium adapted and non-adapted) were treated with insulin (5, 10, 20 and 40 i.u S.C). Thereafter the rats were transferred to metabolic cages and urine volumes, levels of plasma glucose, plasma and urine creatinine/electrolytes/urea, creatinine clearance and lipid profile were determined 24 hours after drug administration.In the potassium adapted diabetic rats, resistance to lower doses of insulin (5, 10 i.u/kg) was observed, suggesting insulin resistance by potassium adaptation. A reduction in the blood glucose level of the potassium-adapted diabetic rats were only possible with the higher doses (20 and 40 i.u/kg) of insulin used. A significant reduction (p<0.05) of the LDL and triglycerides levels was noted in the potassium adapted diabetic rats treated with the different doses of insulin. All the doses of insulin administered increased the creatinine clearance in both potassium adapted normal and diabetic rats, in comparison with those not treated with insulin. It can be concluded that potassium-adaptation induces resistance to hyperglycaemic treatment, as seen with a higher blood glucose level that was non-responsive to treatment with lower doses of insulin.
Keywords: Blood glucose, Diabetes, Hypoglycaemia, Insulin, Potassium adaptation, Streptozotocin.